Table 1 Patients prospectively recruited into the clinical trial. Patient specific information including breed, sex (male castrated (MC) or female spayed (FS)), and age (years old (yo)) is reported. Tumor variant as a conventional/papillary squamous cell carcinoma (SCC) or solid/canine acanthamatous ameloblastoma (CAA) is reported. Tumor location and size is reported using the WHO TNM staging system as T1: <2 cm, T2: 2–4 cm, T3 > 4 cm. Presence of locoregional metastasis and staging methodology is reported. Within this study Sentinel lymph node (SLN) mapping was performed by indirect computed tomography lymphangiography. Lastly, presence of distant metastasis and staging methodology with radiology or computed tomography (CT) is reported.
Patient Number | Dog Signalment | Variant | Tumor size | Tumor Location | Locoregional metastasis, staging performed | Distant Metastasis, staging performed | Time from 5-ALA to imaging | Visual PpIX fluorescence? |
|---|---|---|---|---|---|---|---|---|
Squamous Cell Carcinoma | ||||||||
9 | 6 yo MC Siberian Husky | Conventional SCC | T1 | Rostral mandible | No, histology SLN | No, thoracic CT | 213 min | Yes |
11 | 8 yo FS Labrador Retriever Mix | Conventional SCC | T2 | Rostral mandible | No, histology SLN | No, thoracic CT | 209 min | Yes |
4 | 2 yo MC Australian Shepherd | Papillary SCC transformed from viral papilloma | T3 | Caudal mandible | Unknown, owner declined screening | No, thoracic CT | 225 min | Yes, papilloma at distal end of tumor also fluoresced |
14 | 3 yo MC Golden Retriever | Papillary SCC | T1 | Rostral maxilla | No, cytology bilateral Mandibular LN | No, thoracic CT | 200 min | Yes |
17 | 9 yo MC Miniature Poodle | Conventional SCC | Scar revision, T1 prior to excisional biopsy by rdvm. Final pathology: no cancer | Caudal maxilla/ cheek pouch | No, histology of SLN | No, thoracic CT | 185 min | Yes, near inflammation caudally only in region of previous surgery |
18 | 7 yo MC Labrador Retriever | Conventional SCC | Scar Revision, T1 prior to excisional biopsy at VMTH, no sutures. Final pathology: no cancer | Caudal mandible | No, histology of SLN | No, thoracic CT | 224 min | No |
20 | 10 yo FS Chinese Crested | Conventional SCC | T2 | Caudal mandible | No, histology of SLN | No, thoracic CT | 190 min | Yes |
6 | 13 yo FS Maltese | Conventional SCC | T3 | Rostral-caudal mandible | No, histology from complete lymph node dissection (CLND) | No, thoracic CT | 185 min | Yes |
23 | 12 yo MC Boxer Mix | Conventional SCC | T3 | Rostral mandible | No, histology from CLND | No, thoracic CT | 180 min | Yes |
15 | 10 yo MC Pit Bull | Conventional SCC | T2 | Rostral maxilla | Unknown, owner declined screening | Unknown, owner declined screening | 189 min | Yes |
29 | 13 yo MC Shih Tzu | Conventional SCC | T3 | Caudal Mandible | Yes, histology from CLND | No, thoracic CT | 180 min | Yes, at periphery of tumor only |
Ameloblastoma | ||||||||
16 | 10 yo FS American Eskimo | CAA | T2 | Rostral mandible | No, histology SLN *incisional biopsy looked more consistent with SCC, final was CAA | No, thoracic radiographs | 254 min | Yes |
2 | 9 yo FS English Bulldog | CAA | T1 | Rostral maxilla | Unknown, owner declined screening | Unknown, owner declined screening | 212 min | No * given in pill |
22 | 12 yo FS German Shepherd Dog | CAA | T2 | Caudal maxilla | Unknown, owner declined screening | Unknown, owner declined screening | 170 min | Yes |
27 | 4 yo MC Cocker Spaniel Mix | CAA | T2 | Caudal Maxilla | Unknown, owner declined screening | No, thoracic CT | 185 min | Yes |
