Fig. 1 | Scientific Reports

Fig. 1

From: H19 enhances pancreatic cancer proliferation and invasion by reducing miR-29c-5p’s inhibitory effects on ATF2/ECM1

Fig. 1The alternative text for this image may have been generated using AI.

Expression Dynamics and Subcellular Localization of H19 in Pancreatic Cancer. (A) Quantitative analysis of H19 subcellular localization based on LncLocator, indicating its predominant localization in the cytoplasm and exosomes (exosomes: 80%, nucleus: 10%, cytoplasm: 10%). (B) B.Box plot comparison of H19 expression levels in pancreatic cancer tissues (n = 179) and adjacent normal tissues (n = 171) from the TCGA database, *p < 0.05, **p < 0.01, ***p < 0.001. (C) Kaplan-Meier survival curve stratified by H19 expression in the TCGA database. High H19 levels are associated with poor prognosis (hazard ratio = 1.75, 95% confidence interval: 1.10–2.78; p = 0.018). (D) Relative expression of H19 in pancreatic cancer cell lines (PANC-1, MIA PaCa-2, Capan-2, BxPC-3, CFPAC) and normal HPDE cells. The expression of H19 is upregulated by more than 4-fold in PANC-1 and MIA PaCa-2 cells, *p < 0.05, **p < 0.01, ***p < 0.001. (E) Immunofluorescence staining confirmed the enrichment of H19 (red) in the cytoplasm of PANC-1 and MIA PaCa-2.

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