Fig. 4 | Scientific Reports

Fig. 4

From: Synergistic combinatorial anticancer potential of Tamoxifen with Naringin and Diosmetin in MCF-7 breast cancer cells and their liposomal delivery

Fig. 4

Effect of dual and triple drug combinations on apoptosis-related markers in MCF-7 cells. TMX: Tamoxifen; NRG: Naringin; DMT: Diosmetin. Cells were treated with TMX: NRG (6.25:12.5 µM), TMX: DMT (6.25:12.5 µM), and TMX: NRG: DMT (6.25:12.5:12.5 µM). (A) Western blot analysis of Bcl-2, Bcl-xL, and Cleaved Caspase-3, with β-actin as loading control. (B) Relative protein expression of Bcl-2, Bcl-xL, (C) Relative protein expression of Cleaved Caspase-3. Data represent mean ± SD of three independent experiments. Statistical significance vs. control: p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), p < 0.0001 (****).

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