Fig. 5

UCMSC-Exos reduced inflammatory cytokine expression in neutrophils isolated from eye-draining lymph nodes and in corneal tissues. qPCR analysis Il-1β (A), Il-17 (B), Il-10 (C), Tgf-β (D), and Arg-1 (E) expression by neutrophils isolated from eye-draining lymph nodes. qPCR analysis of Il-10 (F), Arg-1 (G), Tgf-β (H), Il-1β (I), Ifn-γ (J), Il-17 (K) and Tnf-α (L) expression in mouse corneas. Data are presented as mean ± SEM for each group (n = 5). Statistical significance is denoted as follows: ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001 for the Young group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, ^####P < 0.0001 for the Aged group; and ^{^}P < 0.05, ^{^^}P < 0.01, ^{^^^}P < 0.001 for comparisons between the Young and Aged groups. Statistical analyses were performed by one-way ANOVA and Student’s t-test.