Fig. 2 | Scientific Reports

Fig. 2

From: Esketamine attenuates bone cancer pain by suppressing MAPK signaling and glial activation in the spinal dorsal horn of rats

Fig. 2

ESK improves gait performance and anxiety-like behavior. (A) CatWalk: Gait patterns, displaying print view, foot pattern, print intensity, and timing view. (B–E) Quantification of gait alterations: Maximum contact area (B), mean intensity (C), single stance duration (D), and swing duration (E) of the left hind paw compared to the right hind paw. (F) Representative open field test (OFT): Tracks in the three groups, with the central area indicating in red. (G–H) Quantification of OFT parameters: Percentage of total distance traveled and (G) total time spent in the central area (H). Data are mean ± SEM of biological replicates n = 8. *P < 0.05, ***P < 0.001, One-way ANOVA with repeated measures followed by post hoc Tukey test.

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