Fig. 8 | Scientific Reports

Fig. 8

From: Inhibition of galanin receptor 3 slows down retina degeneration in retinitis pigmentosa through modulation of inflammatory and oxidative stress response

Fig. 8

Effects of GALR3 inhibition on BRB integrity in the eyes of RhoP23H/+ mice. The analyses were performed in the following groups of mice: WT, RhoP23H/+, antagonist-treated RhoP23H/+, and RhoP23H/+Galr3−/− at P33 and P45. a Immunofluorescence labeling of ZO-1 on RPE/choroidal flat mounts. b Quantification of RPE cell-cell connections per area. c Detection of albumin leakage on retinal flat mounts with anti-albumin antibody conjugated to fluorescein. d Quantification of fluorescence intensity in retinal tissue. Error bars represent S.D. Statistical analysis was performed with one-way ANOVA and post hoc Turkey’s tests. Statistically significant changes are shown with asterisks. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not statistically significant. P23H/+, RhoP23H/+; P23H/+ SNAP, RhoP23H/+ treated with antagonist; P23H/+Galr3−/−, RhoP23H/+Galr3−/−.

Back to article page