Fig. 4
From: Thermoregulatory adaptations to cold in C3H/HeJ mice are independent of ADRB3 signaling
Pharmacological stimulation of β-adrenergic pathways in C57 and C3H mice. (A-C) Expression of Adrb1 and Adrb3 in BAT (A), iWAT (B), and eWAT (C). (D) Experimental design for crossover administration of CL 316,243. (E) EE following CL 316,243 injection (0.1 mg/kg, i.p.). (F) Average EE over 4 h. (G) RER following CL 316,243 injection. (H) Experimental design for crossover NE and propranolol treatment. (I) EE following NE or propranolol + NE injection. (J) Average EE over 4 h. (K) RER in all treatment groups. Data are shown as mean ± SEM. Statistical analyses were performed using two-way or three-way ANOVA with Bonferroni post hoc tests. *p ≤ 0.05, **p ≤ 0.01 and ***p ≤ 0.0001; n = 6–12/group for A-C; n = 8/group for D-K.
