Fig. 5
From: Immune checkpoint inhibition increases antigen-specific T cell response in head and neck cancer
Co-stimulatory molecules. (A–D) Expression of co-stimulatory molecules and checkpoints on CD8 + cells. (E–H) Expression of co-stimulatory molecules and checkpoints on CD4 + cells. In each case comparing cells with different stimulations: NoP/TAA/TAA + aPD-1. We see a tendency of an increase of co-stimulatory molecules, when we compare NoP (no stimulation) with cells stimulated with a TAA and all the more so with anti-PD-1. (D, H) When the immune checkpoint PD-1 is analyzed, the opposite effect is observed.
