Table 9 In silico prediction of organ toxicity and toxicological endpoints of phytochemicals from the hydroethanolic extract of Solanum obtusifolium Dunal.

From: In vitro and in silico antiglycation antihyperglycemic and anti-inflammatory properties of chemically profiled fruit extracts of Solanum obtusifolium Dunal

Compounds

Organ toxicity

Toxicity end points

 

Hepatotoxicity

Immunotoxicity

Cytotoxicity

Class

LD50 mg/kg

Gallic acid

Inactive

(P = 0.61)

Inactive

(P = 0.99)

Inactive

(P = 0.91)

4

2000

Caffeic acid

Inactive

(P = 0.57)

Inactive

(P = 0.50)

Inactive

(P = 0.86)

5

2980

3–4-dihydroxybenzoic acid

Inactive

(P = 0.59)

Inactive

(P = 0.99)

Inactive

(P = 0.90)

4

2000

Catechin

Inactive

(P = 0.72)

Inactive

(P = 0.96)

Inactive

(P = 0.84)

6

10,000

Quercetin

Inactive

(P = 0.69)

Inactive

(P = 0.87)

Inactive

(P = 0.99)

3

159

Syringic acid

Active

(P = 0.58)

Inactive

(P = 0.97)

Inactive

(P = 0.97)

4

1700

p-Coumaric Acid

Inactive

(P = 0.51)

Inactive

(P = 0.91)

Inactive

(P = 0.81)

5

2850

Ursolic acid

Inactive

(P = 0.62)

Active

(P = 0.95)

Inactive

(P = 0.99)

4

2000

  1. P: Probability; LD50: Lethal Dose 50.