Fig. 4

Structural alignment of CTS docked with CoA and HsABCD1 with substrate C22:0-CoA (7VZB). (a) CTS apo model superimposed to the (b) HsABCD1 with RMSD score of 2.8 Å. (c, d) The location of the CoA of each structure is similar indicating a conserved CoA binding pocket.