Table 3 Differentially expressed genes (DEGs) involved in Parkinson’s disease in Tribolium castaneum strains with homologous human genes.

From: Tribolium castaneum with longer duration of tonic immobility have more variations corresponding to the human Parkinson’s disease genomic region

T. castaneum

RNA-seq analyses

Genomic analyses

Homologous protein ID (human protein)

Human Gene Symbol

E-value

% Identity

SNV

Large-InDel

CNV

PAV

Protein ID

Gene ID

Product (protein)

FPKM for L

FPKM for S

log2 (Fold change + 1)

FDR

L

S

L

S

L

S

L

S

XP_008199415.1

661,524

Insulin-like receptor isoform X1

2.38565

9.54539

−1.63911

0.043611

✔

✔

      

NP_001342145.1

RET

2.42E-64

41

XP_008199416.1

661,524

Insulin-like receptor isoform X1

2.38565

9.54539

−1.63911

0.043611

✔

✔

      

NP_001342145.1

RET

2.42E-64

41

XP_015834738.1

661,524

Insulin-like receptor isoform X1

2.38565

9.54539

−1.63911

0.043611

✔

✔

      

NP_001342145.1

RET

2.42E-64

41

XP_015834746.1

661,524

Insulin-like receptor isoform X2

2.38565

9.54539

−1.63911

0.043611

✔

✔

      

NP_001342145.1

RET

2.53E-64

41

XP_008199510.2

655,556

Uncharacterized protein LOC655556

8.09174

16.6392

−0.95616

0.003524

✔

 

✔

     

NP_006769.2

TRIM10

2.29E-06

48

XP_974991.1

663,867

Proteasome subunit beta type-4

68.3952

123.59

−0.84428

0.003524

✔

       

NP_002787.2

PSMB4

9.89E-96

51

XP_008190792.1

659,195

troponin C, isoform 1

315.193

527.319

−0.74060

0.003524

        

NP_001350599.1

CALM1

1.67E-39

43

XP_975651.1

664,562

Glucosylceramidase

41.8783

69.5296

−0.71798

0.003524

✔

✔

      

NP_001005741.1

GBA1

2.4E-132

41

XP_973521.1

662,326

Heat shock 70 kDa protein cognate 2

26.859

42.7952

−0.65263

0.012025

✔

✔

      

XP_011541100.1

HSPA8

0

76

XP_966407.1

655,491

Tubulin alpha-1 A chain

77.6973

48.5684

0.666893

0.019413

✔

✔

      

NP_006000.2

TUBA1A

0

97

NP_001092299.1

654,918

Tyrosine hydroxylase

50.4661

29.0366

0.776901

0.003524

✔

✔

      

NP_000351.2

TH

2.4E-165

55

XP_015833547.1

655,392

Protein henna isoform X2

80.6237

31.9052

1.310673

0.003524

✔

✔

      

XP_011518637.1

TH

3.2E-149

50

XP_015833548.1

655,392

Protein henna isoform X2

80.6237

31.9052

1.310673

0.003524

✔

✔

      

XP_011518637.1

TH

3.2E-149

50

XP_015833549.1

655,392

Protein henna isoform X2

80.6237

31.9052

1.310673

0.003524

✔

✔

      

XP_011518637.1

TH

3.2E-149

50

XP_967025.1

655,392

Protein henna isoform X1

80.6237

31.9052

1.310673

0.003524

✔

✔

      

NP_000351.2

TH

8.1E-149

50

XP_008197500.1

103,314,151

Caspase-1-like

124.418

35.081

1.797433

0.003524

✔

       

NP_001341709.1

CASP3

1.43E-40

41

  1. SNV: small nucleotide variants, InDel: insertion and deletion, Large-InDel: large-scale insertion and deletion, CNV: copy number variation, PAV: presence/absence variation.
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