Fig. 9 | Scientific Reports

Fig. 9

From: Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery

Fig. 9

MRI detection of iron-labelled Wharton’s Jelly–derived mesenchymal stem cells (WJ-MSCs) in the cerebrospinal fluid after intrathecal infusion. MRI images obtained during and after cell administration showing characteristic hypointense areas (marked by red arrows and frames) corresponding to iron-labelledcells. (A) Sagittal planeview showing the localization of the signal approximately 10 cm above the draininsertionsite; (B) coronalplane confirming the spatial distribution of the signal within the spinal canal; (C) sagittalplane with hemo-expansion sequence allowing enhanced visualization of iron-related hypointensity; (D) transverseplane demonstrating cross-sectional localization of the signal within the cerebrospinal fluid compartment. The hypointenseareas correspond to the presence of superparamagnetic iron-labeled MSCs, confirming their localization within the subarachnoid space and the absence of pathological changes in surrounding tissues.

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