Table 1 Distribution of the asymmetrical and symmetrical high-mannose glyco-pairs in the MR-AC fractions determined by RPC-MS after Endo F3 digestion.
From: Selective clearance of monoclonal antibodies via the mannose receptor is dependent on glycan pairing
Glyco-pair | mAb1 | mAb2 | ||||
|---|---|---|---|---|---|---|
F1/2 | F3 | F4 | F1/2 | F3 | F4 | |
Symmetrical complex glyco-pair | 71% | 13% | - | 85% | 22% | - |
Asymmetrical high-mannose glyco-pair | 29% | 87% | - | 15% | 78% | - |
Symmetrical high-mannose glyco-pair | - | - | 100% | - | - | 100% |
