Plate 1.
From: Cardioprotective effects of curcumin and piperine against obesity induced oxidative stress in rats
Photomicrograph of hematoxylin and eosin (H&E) stained heart sections in control (A), DMSO (B), and curcumin plus piperine (C) groups showed normal appearance and well organization of cardiac muscle fibers (arrow) with minimal interstitial space and intact intercalated discs containing connective tissue and blood vessels, acidophilic sarcoplasm and centrally located nuclei (arrowhead). Cardiac section from HFD group (D) showing markedly increased interstitial space (asterisk) with degenerated muscle fibers (arrow), inflammatory cell infiltration and congested blood vessels (curved arrow), and pyknotic nuclei (arrowhead). However, HFD rats treated with curcumin plus piperine (E) showing markedly decreased interstitial space (asterisk) with increased size of muscle fibers (arrow) and presence of centrally located nuclei (arrowhead).
