Fig. 5 | Scientific Reports

Fig. 5

From: High-intensity interval training remodels perineuronal nets in the medial prefrontal cortex to drive microglial polarization and alleviate osteoarthritis pain

Fig. 5The alternative text for this image may have been generated using AI.

PNNs degradation and HIIT alleviate neuroinflammation in the mPFC of OA rats. (A-D) Representative triple immunofluorescence staining images of the mPFC, showing the distribution patterns of PNNs, Iba1 (microglial marker), and iNOS (A) or Arg1 (C). Quantification of panel A is shown in (B), and quantification of panel C is shown in (D) (n = 6). (E and F) Western blot analysis and corresponding quantification of inflammatory markers, including iNOS, Arg1, IL-1β, TNF-α, and IL-10 in mPFC tissue lysates (n = 6). Statistical methods used: One-way ANOVA. **p < 0.01 vs. the OA+Vehicle group, ns not significant vs. the OA+ChABC group.Data are presented as mean ± SD.

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