Table 4 Multivariable Cox analyses for risk factors associated with the kidney outcome according to sex-specific Hb cut-offs (entire cohort).
Variables (n = 459, event = 136) | Multivariable analysis (Model 5 for Hb < 12.0 g/ dL in men, Hb < 11.0 g/ dL in women) | Multivariable analysis (Model 6 for Hb < 13.0 g/ dL in men, Hb < 12.0 g/ dL in women) | ||
|---|---|---|---|---|
Hazard Ratio (95% CI) | P– value | Hazard Ratio (95% CI) | P– value | |
Age (10 year increase) | 0.63 (0.52–0.74) | < 0.0001* | 0.62 (0.52–0.74) | < 0.0001* |
Female sex (vs. male sex) | 1.64 (1.06–2.54) | 0.0273* | 1.53 (0.99–2.37) | 0.0553 |
eGFR (10 mL/min/1.73m2 increase) | 0.47 (0.40–0.54) | < 0.0001* | 0.49 (0.41–0.57) | < 0.0001* |
Anemia of Hb < 12.0 g/ dL in men, Hb < 11.0 g/ dL in women | 1.89 (1.19–2.98) | 0.0066* | – | – |
Anemia of Hb < 13.0 g/ dL in men, Hb < 12.0 g/ dL in women | – | – | 2.11 (1.33–3.34) | 0.0015* |
Hypertension (vs. no) | 1.67 (1.08–2.60) | 0.0214* | 1.63 (1.08–2.57) | 0.0222* |
Low HDL cholesterol (vs. no) | 0.96 (0.58–1.55) | 0.8785 | 0.97 (0.59–1.59) | 0.9072 |
Hyperuricemia (vs. no) | 1.14 (0.70–1.86) | 0.5959 | 1.24 (0.76–2.01) | 0.3924 |
Overweight (BMI ≥ 25 kg/m2) | 1.53 (0.98–2.35) | 0.0539 | 1.60 (1.03–2.48) | 0.0351* |
U-Prot (≥ 0.15 g/ gཥCre) | 2.76 (1.81–4.26) | < 0.0001* | 3.22 (2.08–5.00) | < 0.0001* |
TKV (100 mL/m increase) | 1.01 (1.00–1.03) | 0.0351* | 1.01 (1.00–1.03) | 0.0449* |