Table 4 Multivariable Cox analyses for risk factors associated with the kidney outcome according to sex-specific Hb cut-offs (entire cohort).

From: Association of anemia with long-term renal prognosis in autosomal dominant polycystic kidney disease using time-series analysis

Variables

(n = 459, event = 136)

Multivariable analysis

(Model 5 for Hb < 12.0 g/ dL in men, Hb < 11.0 g/ dL in women)

Multivariable analysis

(Model 6 for Hb < 13.0 g/ dL in men, Hb < 12.0 g/ dL in women)

Hazard Ratio

(95% CI)

P

value

Hazard Ratio

(95% CI)

P

value

Age (10 year increase)

0.63 (0.52–0.74)

< 0.0001*

0.62 (0.52–0.74)

< 0.0001*

Female sex (vs. male sex)

1.64 (1.06–2.54)

0.0273*

1.53 (0.99–2.37)

0.0553

eGFR (10 mL/min/1.73m2 increase)

0.47 (0.40–0.54)

< 0.0001*

0.49 (0.41–0.57)

< 0.0001*

Anemia of Hb < 12.0 g/ dL in men, Hb < 11.0 g/ dL in women

1.89 (1.19–2.98)

0.0066*

Anemia of Hb < 13.0 g/ dL in men, Hb < 12.0 g/ dL in women

2.11 (1.33–3.34)

0.0015*

Hypertension (vs. no)

1.67 (1.08–2.60)

0.0214*

1.63 (1.08–2.57)

0.0222*

Low HDL cholesterol (vs. no)

0.96 (0.58–1.55)

0.8785

0.97 (0.59–1.59)

0.9072

Hyperuricemia (vs. no)

1.14 (0.70–1.86)

0.5959

1.24 (0.76–2.01)

0.3924

Overweight (BMI ≥ 25 kg/m2)

1.53 (0.98–2.35)

0.0539

1.60 (1.03–2.48)

0.0351*

U-Prot (≥ 0.15 g/ gཥCre)

2.76 (1.81–4.26)

< 0.0001*

3.22 (2.08–5.00)

< 0.0001*

TKV (100 mL/m increase)

1.01 (1.00–1.03)

0.0351*

1.01 (1.00–1.03)

0.0449*

  1. Variables of general risk factors for kidney disease progression in autosomal dominant polycystic kidney disease and chronic kidney disease were included in the multivariable models. Abbreviation: eGFR, estimated glomerular filtration rate; RRT, renal replacement therapy; n, number; CI, confidence interval; Hb, hemoglobin; Anemia of Hb < 11.0 g/ dL, Hb level < 11 g/dL, or taking iron or erythropoiesis-stimulating agents (ESA); Anemia of Hb < 12.0 g/ dL, Hb level < 12 g/dL, or taking iron or ESA; Anemia of Hb < 13.0 g/ dL, Hb level < 13 g/dL, or taking iron or ESA; HDL, high-density lipoprotein; BMI, body mass index; U-Prot, Urinary protein excretion; TKV, total kidney volume.