Table 3 ADME parameters including physiochemical and pharmacokinetics features of Carvacrol bioactive compound.

From: Carvacrol from Moringa oleifera as a potential antidiabetic agent using integrated in-silico approach inhibiting TCF7L2

ADME Parameters

Physiochemical properties

Formula

C10H20O

Molecular weight

169.37 g/mol

Num. heavy atoms

11

Num. from. Heavy atoms

0

Fraction Csp3

1.00

Num. rotatable bonds

1

Num. H-bond acceptors

1

Num. H-bond donors

1

Molar Refractivity

49.23

TPSA

20.23 Ų

Lipophilicity

Log Po/w

2.29

Water Solubility

Log S (ESOL)

−2.73

Class

Soluble

Pharmacokinetics

GI absorption

High

BBB permeant

Yes

Log Kp (skin permeation)

−5.19 cm/s

Back to article page