Table 1 Serum concentrations of bone metabolism and inflammatory biomarkers in male and female Wistar rats following dietary vitamin D supplementation.

GH, ng/ml

10.73 ± 1.08^a

8.90 ± 1.61^a

10.62 ± 2,19^a

4.48 ± 1.06^b

5.63 ± 1.09^b

5.96 ± 1.25^b

OC, ng/ml

13.53 ± 4.40^c

20.08 ± 6.59^b

17.57 ± 2.70^b

26.93 ± 8.87^b

30.44 ± 6.81^a

13.22 ± 3.82^c

OPG, pg/ml

549.96 ± 84.98^a

479.13 ± 74.80^b

509.08 ± 136.39^b

443.49 ± 133.82^b

347.29 ± 66.07^c

452.36 ± 90.54^b

RANKL, pg/ml

36.78 ± 8.99^b

63.34 ± 16.86^a

49.67 ± 15.62^b

53.65 ± 20.41^a

40.71 ± 15.22^b

35.42 ± 10.07^b

IGF-1, ng/ml

921.77 ± 115.57

884.64 ± 191.21

1067.35 ± 150.89

953.70 ± 100.35

982.55 ± 73.12

887.32 ± 197.15

IL-1, pg/ml

20.05 ± 4.46

17.53 ± 1.09

19.23 ± 3.64

18.45 ± 1.74

19.57 ± 1.13

19.39 ± 0.43

IL-6, pg/ml

23.16 ± 4.49

18.90 ± 5.35

23.29 ± 5.83

18.72 ± 3.46

18.89 ± 6.33

18.95 ± 1.91

IL-10, pg/ml

41.15 ± 6.46^b

84.14 ± 12.34^a

39.50 ± 5.02^b

16.83 ± 9.16^c

15.90 ± 5.07^c

35.25 ± 5.71^b

TNFα, pg/ml

43.48 ± 8.41^a

32.85 ± 3.03^b

39.89 ± 5.87^a

28.21 ± 2.50^c

22.26 ± 1.04^d

32.71 ± 2.49^b

BALP, ng/ml

8.20 ± 2.52

9.41 ± 3.26

9.27 ± 3.09

6.89 ± 0.26

8.94 ± 3.29

9.38 ± 3.32

RANKL/OPG

0.067 ± 0.01^c

0.132 ± 0.03^a

0.098 ± 0.01^c

0.118 ± 0.01^b

0.115 ± 0.03^b

0.079 ± 0.01^c