Table 1 Regression and analytical parameters of the proposed RP-HPLC method for the determination of BBL and MTK.

From: Eco-friendly RP-HPLC determination of bambuterol hydrochloride and montelukast sodium in tablet dosage with dissolution analysis

Parameter

BBL

MTK

Linearity

 Range (µg/ml)a

(1.2–100.0)

(5.0–100.0)

 Slope

23.597

61.018

 SE of the slope

0.482

0.506

 Intercept

-1.4184

15.183

 SE of the Intercept

0.257

0.306

 Correlation Coefficient (r²)

0.9999

0.9999

 LOD( µg/ml)

0.052

0.113

 LOQ( µg/ml)

0.159

0.344

 Accuracy (Mean% ± SD)

100.92 ± 1.08

99.39 ± 1.41

Precision (RSD%)

 Repeatability b

0.542

1.204

 Intermediate Precision c

1.744

1.790

  1. a Based on slope (m) and intercept (b), the concentration at which the intercept contributes 5% of total signal is C* = (|b|/0.05 − b)/m. Using the reported parameters, C* ≈ 1.14 µg/mL (BBL) and 4.73 µg/mL (MTK). Working ranges were set just above C*.
  2. b The intraday RSD (n = 9), of determinations of (10, 20, 30 µg/mL) of BBL and MTK, repeated three times within the day.
  3. c The interday RSD (n = 9), of determinations of (10, 20, 30 µg/mL) of BBL and MTK, repeated three times in three different days.
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