Table 3 Robustness of the proposed RP-HPLC method.

From: Eco-friendly RP-HPLC determination of bambuterol hydrochloride and montelukast sodium in tablet dosage with dissolution analysis

Parameters

Flow rate (mL/min)

Column temperature °C

pH values

Ethanol %

 

0.9

1.1

23

27

2.9

3.1

68

72

Measured K

BBL

1.94

1.29

1.66

1.64

1.67

1.48

1.70

1.61

MTK

20.36

15.47

22.60

20.29

18.43

15.42

27.33

16.27

Resolution Rs

BBL

        
 

16.695

13.953

15.958

16.542

14.930

12.785

18.151

15.559

MTK

        

Selectivity α

BBL

        
 

10.49

11.99

13.61

12.37

11.04

10.42

16.08

10.11

MTK

        

Assay % a

BBL

100.6

99.671

100.78

100.17

101.1

100.3

100.12

99.34

MTK

100.6

99.118

100.06

99.49

100.5

100.6

101.05

99.24

RSD % b

BBL

0.349

0.7628

0.69

0.5304

1.583

0.652

0.6676

1.412

MTK

1.862

0.8851

1.4295

0.7558

1.235

0.824

0.3625

0.229

  1. a % Average assay of three determinations calculated from the regression equations.
  2. b % RSD of three determinations.
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