Table 1 Percentage of mice (n = 10 per group) dead after experimental decompression (1 min) as a function of environmental pressure expressed in ATA (atmosphere). Mice were injected intraperitoneally with saline (0.5 mL) or GYY4137 (50 mg/kg in 0.5 mL saline), a H₂S donor, half an hour before experimental decompression. During the decompression procedure the air flow was 500 to 600 l/min pending on suitable deepth to reach atmospheric pressure (1 ATA) at the end. The Mann-Whithney test was used for the comparison between saline and CGS21680. The LD₅₀ in the saline group was below 11 ATA (corresponding to a depth of 100 m), as 60% of mice died after the decompression procedure (Table 1). The calculated LD₁₀₀ for the GYY4137 group (expressed as the equivalent depth) is 120 + 20 × 22/10 = 144 m. Assuming that the LD₅₀ of the saline group is below 100 m (Table 1), the LD₁₀₀ in this group would be below 128 m (Table 2).

From: Therapeutic Potential of GYY4137 in Reducing Oxidative Stress and Mortality in Experimental Decompression Sickness