Fig. 1
From: Local ice cryotherapy reduced vascular inflammation in large artery from rats with arthritis

Local ice cryotherapy reduced arthritis severity and joint damage in AIA rats. Experiments were conducted in AIA rats treated or not with daily local ice cryotherapy from day 11 to day 24 post-immunization. (A) Time-course of arthritis score. (B) Radiographic score and (C) representative X-ray radiography of hind paws at day 24. (D–I) Effect of ice cryotherapy on each item of the radiographic score: swelling, cartilage destruction, osteoporosis, bone erosion and new bone formation. Results are expressed as means ± SEM (n = number of rats/group). *(p < 0.05), **(p < 0.01).