Abstract
The association between uterine fibroids and hypertension is not yet settled. Thus, this study aimed to investigate the association between fibroids and hypertension in women of reproductive age in Sudan. A matched case–control study (107 in each arm) was conducted at New Halfa Hospital, Eastern Sudan. The cases were nonpregnant women of reproductive age diagnosed with uterine fibroids confirmed by ultrasound, while the controls were nonpregnant women without uterine fibroids. The women’s sociodemographic characteristics and clinical data were assessed via a questionnaire. Conditional logistic regression analysis was performed. There was no significant difference between the two groups regarding age, parity, body mass index (BMI), and hemoglobin. However, compared with the controls, a significantly higher number of women with uterine fibroids had hypertension, [46 (43.0%) versus 22 (20.6%), P = 0.001]. Multivariable logistic regression showed that women with hypertension (adjusted odds ratio [AOR] = 2.26, 95% confidence interval [CI] 1.14–4.48) were positively associated with uterine fibroids. BMI, education level, occupational status, and marital status were not associated with uterine fibroids. Our study revealed that uterine fibroids are significantly positively associated with hypertension among women of reproductive age in Sudan. This supports the literature calling for further analysis of the shared risk factors and underlying mechanisms of such an interconnected association between hypertension and uterine fibroids.
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The data supporting the current study’s findings are available from the corresponding author upon reasonable request.
References
Akerele, A. T. et al. Uterine fibroids show evidence of shared genetic architecture with blood pressure traits. Pac. Symp. Biocomput. 30, 281–295 (2025).
Alieva Sholpan, U., Aitzhan, A. & Sekenova, K. Uterine fibroids: Retrospective study with analysis of different risk factors. Int. J. Women’s Heal Wellness. 9, 152 (2023).
Stewart, E. A., Cookson, C. L., Gandolfo, R. A. & Schulze-Rath, R. Epidemiology of uterine fibroids: A systematic review. BJOG Int. J. Obstet. Gynaecol. 124, 1501–1512 (2017).
Chen, Y. et al. Uterine fibroids increase the risk of hypertensive disorders of pregnancy: A prospective cohort study. J. Hypertens. 39, 1002–1008 (2021).
Henry, J., Brewster, L. M., Blood & Pressure cardiometabolic traits, and cardiovascular events in women with uterine fibroids: A genetic correlation and mendelian randomization study. J. Am. Heart Assoc. 14, e036697 (2025).
Haan, Y. C. et al. Hypertension risk in Dutch women with symptomatic uterine fibroids. Am. J. Hypertens. 28, 487–492 (2015).
Vodouhe, M. V. et al. Associated factors and consequences of uterine fibroids in hospitals in the Borgou Department of Benin in 2022. Adv. Reprod. Sci. 12, 60–74 (2024).
Mirdamadi, N., Najafian, A., Kargar, Z. & Adabi, K. The Association between uterine leiomyoma and hypertension: A single center case–control study. JCI Insight. 6, 689–694 (2023).
Stewart, E. A. & Borah, B. J. Uterine fibroids and hypertension: Steps toward understanding the link. J. Clin. Endocrinol. Metab. 106, E1039–E1041 (2021).
Mitro, S. D. et al. Cardiovascular risk factors, and uterine fibroid diagnosis in midlife. JAMA Netw. Open. 7, E246832 (2024). Hypertension.
Haan, Y. C. et al. The risk of hypertension and cardiovascular disease in women with uterine fibroids. J. Clin. Hypertens. 20, 718–726 (2018).
Boynton-Jarrett, R., Rich-Edwards, J., Malspeis, S., Missmer, S. A. & Wright, R. A prospective study of hypertension and risk of uterine leiomyomata. Am. J. Epidemiol. 161, 628–638 (2005).
Poulter, N. R., Prabhakaran, D. & Caulfield, M. Hypertension. The Lancet 386, 801–812 (2015).
Karadeniz Tıp Dergisi, B. Yağlı Karaciğer Hastalığı Olan Çocuklarda Lipid Profilleri ve Vitamini Düzeylerinin Yağlı Karaciğer Derecesi Üzerindeki Etkileri Arzu GÜLSEREN, N.-A. D. & Gülcü Taşkin, D. Effects of Lipid Profiles and Vitamin D Levels on the Degree of Fatty Liver in Children with Non-Alcoholic Fatty Liver Disease. Med. J. West. Black Sea 9, 181–186 (2025).
Ivanova, M., Soule, A., Pudwell, J. & Bougie, O. The association of vitamin D with uterine fibroids in premenopausal patients: A systematic review and meta-analysis. J. Obstet. Gynaecol. Can. 46, 102632 (2024).
Latic, N., Erben, R. G. & Vitamin D and cardiovascular disease, with emphasis on hypertension, atherosclerosis, and heart failure. Int. J. Mol. Sci. 21, 1–15 (2020).
Abdelmtalab, M. A. A., Tahir, O., Hussein, K. & Badawi, K. Anatomical locations of uterine fibroids in Sudanese women. Anat. J. Afr. 9, 1701–1706 (2020).
Omar, S. M., Musa, I. R., Osman, O. E. & Adam, I. Prevalence and associated factors of hypertension among adults in Gadarif in eastern Sudan: A community-based study. BMC Public. Health. 20, 291 (2020).
Omar, S. M., Elnour, O., Adam, G. K., Osman, O. E. & Adam, I. Assessment of blood pressure control in adult hypertensive patients in eastern Sudan. BMC Cardiovasc. Disord. 18, 26 (2018).
UNICEF. State Profile Kassala. (2022).
Cuschieri, S. The STROBE guidelines. Saudi J. Anaesth. 13, S31–S34. https://doi.org/10.4103/sja.SJA_543_18 (2019).
Obesity. preventing and managing the global epidemic: Report of a WHO consultation. https://apps.who.int/iris/handle/10665/42330
Weber, M. A. et al. Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. J. Clin. Hypertens. (Greenwich). 16, 14–26 (2014).
Abdelrahman, E. G., Gasim, G. I., Musa, I. R., Elbashir, L. M. & Adam I. Red blood cell distribution width and iron deficiency anemia among pregnant Sudanese women. Diagn. Pathol. 7, 168 (2012).
Orekoya, O. et al. Comparative plasma levels of angiotensin ii in women with or without uterine fibroid in Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria. J. Gynecol. Res. Rev. Rep. 4, 1–6 (2022).
Akram, S., Akmal, A., Ahmad, S., Ahmad, H. & Roohi, N. Clinicopathological patterns and biochemical markers in serum of uterine leiomyoma patients. Albus Sci. e221025 (2022). (2022).
AlAshqar, A. et al. Oxidative stress and antioxidants in uterine fibroids: Pathophysiology and clinical implications. Antioxidants 12, 807 (2023).
Sahoo, D. K., Samanta, L., Kesari, K. K., Mukherjee, S. & Editorial Hormonal imbalance-associated oxidative stress and protective benefits of nutritional antioxidants. Front. Endocrinol. (Lausanne). 15, 1368580 (2024).
Sellem, L. et al. Food additive emulsifiers and risk of cardiovascular disease in the NutriNet-Santé cohort: Prospective cohort study. Bmj 382, e076058 (2023).
Acknowledgements
We want to thank the women who participated in the study. The researchers would like to thank the Deanship of Graduate Studies and Scientific Research at Qassim University for financial support (QU-APC-2026).
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A.A.A., O.A.H., and I.A. contributed to the study’s design and supervised the data collection. O.A.H., N.A., and I.A. contributed to the data analysis. All authors contributed to the preparation of the manuscript, this version of which they have read and agreed to.
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Abdallah, A.A., Hassan, O.A., AlHabardi, N. et al. Association between uterine fibroids and hypertension among women of reproductive age in Eastern Sudan: a matched case–control study. Sci Rep (2026). https://doi.org/10.1038/s41598-026-42224-5
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DOI: https://doi.org/10.1038/s41598-026-42224-5
