Table 2 Cytotoxic activity (IC50) and selectivity indices (SI) of Moringa oleifera extracts and fractions against cancer cell lines compared to normal human PBMCs.
Sample code | PBMC IC50 (µg/mL) | Cancer cell line | IC50 (µg/mL) | SI |
|---|---|---|---|---|
Ethanolic extract | 624.31 ± 29.07 | MCF-7 | 51.53 ± 2.05 | 12.1 |
HepG-2 | 29.68 ± 0.63 | 21 | ||
CACO2 | 54.82 ± 0.78 | 11.4 | ||
Panc-1 | 52.57 ± 2.19 | 11.9 | ||
A-549 | 46.46 ± 1.79 | 13.4 | ||
HeLa | 61.90 ± 0.53 | 10.1 | ||
Ethyl Acetate fraction | 77.76 ± 2.1 | MCF-7 | 81.93 ± 3.98 | 0.9 |
HepG-2 | 60.71 ± 0.42 | 1.3 | ||
CACO2 | 89.88 ± 2.28 | 0.8 | ||
Panc-1 | 117.13 ± 2.52 | 0.6 | ||
A-549 | 113.51 ± 4.09 | 0.7 | ||
HeLa | 112.32 ± 1.89 | 0.7 | ||
Methylene chloride fraction | 114.59 ± 3.47 µg/mL | MCF-7 | 104.11 ± 1.91 | 1.1 |
HepG-2 | 110.87 ± 1.91 | 1 | ||
CACO2 | 113.80 ± 1.73 | 1 | ||
Panc-1 | 93.00 ± 1.27 | 1.2 | ||
A-549 | 110.13 ± 4.77 | 1 | ||
HeLa | 122.39 ± 0.97 | 0.9 | ||
Butanol extract | 126.92 ± 2.91 | MCF-7 | 218.11 ± 2.08 | 0.6 |
HepG-2 | 119.22 ± 2.12 | 1.1 | ||
CACO2 | 158.38 ± 5.90 | 0.8 | ||
Panc-1 | 231.92 ± 4.76 | 0.5 | ||
A-549 | 211.66 ± 10.29 | 0.6 | ||
HeLa | 214.67 ± 4.18 | 0.6 | ||
Hexane extract | 93.27 ± 1.27 µg/mL | MCF-7 | 14.81 ± 0.32 | 6.3 |
HepG-2 | 18.34 ± 0.76 | 5.1 | ||
CACO2 | 24.78 ± 1.04 | 3.8 | ||
Panc-1 | 43.82 ± 2.41 | 2.1 | ||
A-549 | 20.48 ± 0.10 | 4.6 | ||
HeLa | 30.44 ± 0.49 | 3.1 | ||
Vinblastine Sulfate | of 164.08 ± 0.78 µg/mL | MCF-7 | 3.78 ± 0.54 | 4.89 |
HepG-2 | 3.68 ± 0.17 | 5.02 | ||
CACO2 | 50.3 ± 6.10 | 0.36 | ||
Panc-1 | 13.27 ± 0.94 | 1.39 | ||
A-549 | 2.84 ± 0.32 | 6.51 | ||
HeLa | 6.14 ± 0.92 | 3.01 |
