Fig. 2
Dose-dependent effect of STZ on blood glucose in female NSG mice. Changes in blood glucose values in mmol/L over 10 days in STZ-treated female NSG mice are shown vs. mock controls. The mice were injected i.p. with 125 (a), 150 (b), 175 (c), 200 (d), or 225 mg/kg STZ per kg body weight (e). Separate curves are presented for diabetic (responders) and non-diabetic animals (non-responders). Data are presented as means ± SD, n = 10. The groups were compared on individual days with Student’s t-test, corrected for multiple comparisons by the Bonferroni-Dunn method, resulting in adjusted p-values: *** p ≤ 0.001, ** p ≤ 0.01, * p ≤ 0.05. In (f), a summary of the blood glucose changes of all diabetic animals (responders) is presented. The dotted line indicates the threshold for diabetes induction after two consecutive blood glucose measurements above 15 mmol/L.
