Fig. 4
Kaplan-Meier survival analysis and changes of beta cell survival after STZ treatment. (a) The probability of diabetes manifestation (15 mmol/L threshold) in female NSG mice after treatment with STZ ranged from 125–225 mg/kg STZ per kg body weight compared to the mock control (in teal) over the time course of the study. Statistical differences were calculated using the Log-rank (Mantel-Cox) test. (b) Shown is an immunohistochemical staining of insulin of pancreatic sections obtained from vehicle-treated NSG mice, NSG mice with 125 mg STZ/kg body weight, 175 mg STZ/kg body weight, 225 mg STZ/kg body weight. Arrows point on densely stained beta cells, arrowheads denote to degranulated beta cells with faint insulin staining. 40x magnification.
