Abstract
High-altitude environments pose significant challenges to human cognition due to hypoxic conditions. The long-term effects of chronic high-altitude exposure on cognitive functions remain poorly understood. Cognitive decline in this age group may compromise academic performance, occupational safety and future productivity. In this 4-year longitudinal study, we examined 69 college freshmen who relocated from sea level to the high-altitude region of Tibet. Over four years, we conducted comprehensive cognitive assessments and brain MRI scans at baseline, year two, and year four. Behavioral data revealed persistent impairments in cognitive functions such as working memory and psychomotor function among those exposed to high altitudes for extended periods. Neuroimaging analyses demonstrated a notable decrease in gray matter volume and resting-state brain activities, specifically in the left putamen. These neural alterations were significantly correlated with the observed cognitive deficits, and importantly, the effect of exposure time on working memory was mediated by the left putamen volume. Chronic high-altitude exposure in otherwise healthy young adults is associated with enduring cognitive deficits and convergent structural and functional alterations in the left putamen. These findings highlight cognitive health as an important but under-recognized public-health concern in populations who study or work at high altitude, and suggest that monitoring and preventive strategies may be warranted for long-term high-altitude migrants.
Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Funding
This study was supported by the National Natural Science Foundation of China (No. 82471556, 82101610, 82271920, 82404215), China Postdoctoral Science Foundation (No. 2023M732156), Basic Research Program of Shanxi Province (No. 202403021212088), Doctoral Research Initiation Fund Project (No. XD2103).
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**Hong Li: ** Supervision, Formal analysis, Funding acquisition, Writing-original draft. **Qian Zhang, Siyao Zeng, and Yang Zhou: ** Data curation, Writing-review & editing. **Xinqin Liu and Wenbin Zhang: ** Investigation, Resources. **Wenjing Luo: ** Supervision. **Yazhuo Kong and, Xiaoming Chen: ** Writing-review & editing. All authors contributed to and have approved the final manuscript.
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Li, H., Zhang, Q., Zeng, S. et al. Chronic high-altitude exposure and cognitive health in Chinese college students: a 4-year longitudinal neuroimaging study. Sci Rep (2026). https://doi.org/10.1038/s41598-026-42645-2
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DOI: https://doi.org/10.1038/s41598-026-42645-2
