Table 7 Statistical comparison between the proposed method and the reported one for the determination of BOS.

From: Sensitive voltammetric detection of bosentan using gold nanoparticles-decorated pencil graphite electrode in pharmaceutical formulations and plasma samples

Parameter

Reported method* (13)

Proposed method

Mean

99.83

99.35

SD

0.45

0.88

Variance

0.20

0.77

N

3.0

5.0

Student t-test (2.447)

 

0.86

F (19.247)

 

3.85

  1. * Inertsil C8 column (5 µ, 15 cm x 4.6 mm) followed by a guard column CLC ODS (4 cm x 4.6 mm, i.d.) was used for chromatographic separation by isocratic elusion. acetate buffer (pH 5.5) and acetonitrile in the ratio of 20:80 (v/v) were used as mobile phase with a flow of 1.0 mL/min.
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