Table 2 Serum cytokines and chemokines in control vs. CD.
From: Non-invasive determination of disease activity in Crohn’s disease by serum luminex profiling
Analyte | Control (n = 40) | CD (n = 103) | p | q |
|---|---|---|---|---|
TGFα | 3.29 (2.04–6.13) | 6.29 (3.95–9.73) | < 0.001 | 0.001 |
IFNα2 | 4.06 (1.79–12.70) | 12.67 (6.90–24.99) | < 0.001 | 0.006 |
Fractalkine | 83.04 (52.60–112.32) | 114.31 (76.63–187.15) | 0.001 | 0.018 |
PDGF-AA | 5878.00 (4542.50–7565.50) | 7546.00 (5676.00–9620.50) | 0.002 | 0.018 |
IL13 | 6.74 (0.73–32.49) | 30.24 (8.84–68.35) | 0.002 | 0.020 |
IL25 | 1153.00 (769.40–2210.50) | 2182.50 (1286.25–3432.75) | 0.004 | 0.029 |
IL6 | 0.88 (0.37–1.79) | 2.16 (0.65–3.79) | 0.007 | 0.035 |
MCP3 | 22.18 (14.14–33.32) | 29.22 (21.58–39.88) | 0.006 | 0.035 |
PDGF-ABBB | 41872.00 (32268.00–51592.50) | 49034.00 (36061.75–64495.50) | 0.007 | 0.035 |
GROα | 26.19 (19.53–39.49) | 36.31 (24.29–55.42) | 0.012 | 0.039 |
IL4 | 6.75 (5.52–8.35) | 8.07 (6.38–9.88) | 0.012 | 0.039 |
IL10 | 1.19 (0.52–2.37) | 1.96 (0.82–5.62) | 0.011 | 0.039 |
MCSF | 9.61 (7.25–21.56) | 23.25 (8.29–44.82) | 0.011 | 0.039 |
IL1β | 0.27 (0.21–1.71) | 0.72 (0.27–8.91) | 0.015 | 0.041 |
IL17F | 5.27 (2.63–11.04) | 13.2 (3.45–50.40) | 0.014 | 0.041 |
IL18 | 73.15 (46.76–117.94) | 94.39 (56.79–159.02) | 0.016 | 0.042 |
FGF2 | 26.70 (18.44–58.52) | 57.33 (28.07–100.69) | 0.023 | 0.057 |
IP10 | 225.14 (170.01–265.66) | 166.34 (125.04–252.25) | 0.027 | 0.063 |
GCSF | 54.83 (38.56–69.32) | 60.83 (46.82–95.95) | 0.030 | 0.064 |
IFNγ | 1.64 (0.47–4.71) | 2.87 (1.20–8.04) | 0.031 | 0.064 |
IL1RA | 3.08 (1.67–5.38) | 4.40 (2.56–7.55) | 0.032 | 0.064 |
IL12p70 | 0.74 (0.47–1.55) | 1.12 (0.65–2.20) | 0.038 | 0.072 |
MIP1β | 41.13 (35.37–53.61) | 37.84 (28.06–48.41) | 0.055 | 0.101 |
IL2 | 0.08 (0.06–0.16) | 0.16 (0.06–0.29) | 0.065 | 0.105 |
IL9 | 14.77 (5.20–46.48) | 30.70 (9.38–57.08) | 0.065 | 0.105 |
MCP1 | 599.36 (520.86–742.30) | 551.60 (414.59–682.39) | 0.060 | 0.105 |
IL12p40 | 38.18 (19.57–54.08) | 46.13 (21.10–107.16) | 0.089 | 0.138 |
IL8 | 7.05 (5.57–8.99) | 5.91 (4.37–8.87) | 0.098 | 0.147 |
CXCL9 | 2594.00 (2051.00–3286.00) | 2923.00 (2062.00–4750.50) | 0.103 | 0.149 |
TNFα | 22.80 (17.52–27.36) | 27.56 (16.33–39.85) | 0.109 | 0.153 |
FLT3L | 14.43 (11.49–18.43) | 13.08 (9.48–17.04) | 0.134 | 0.181 |
VEGF-A | 439.52 (195.92–534.62) | 389.37 (270.05–670.21) | 0.199 | 0.262 |
EGF | 66.62 (45.94–104.81) | 85.42 (51.67–127.86) | 0.221 | 0.273 |
IL7 | 3.56 (2.16–5.33) | 4.40 (2.59–6.73) | 0.216 | 0.273 |
MDC | 710.36 (593.52–841.51) | 741.70 (557.35–1131.75) | 0.350 | 0.419 |
MIP1α | 8.16 (2.17–25.74) | 11.21 (5.03–23.83) | 0.369 | 0.430 |
sCD40L | 9438.00 (5458.50 -16089.50) | 8768.50 (5383.25–13017.25) | 0.484 | 0.549 |
Eotaxin | 117.91 (81.98–148.91) | 122.03 (91.18–162.68) | 0.539 | 0.581 |
IL5 | 2.67 (1.82–4.24) | 3.08 (1.47–6.42) | 0.535 | 0.581 |
IL15 | 2.78 (1.43–4.75) | 2.72 (1.34–4.04) | 0.740 | 0.777 |
IL1α | 1.42 (1.31–2.76) | 1.42 (1.23–4.58) | 0.790 | 0.809 |
IL27 | 1512.00 (1201.50–1868.25) | 1508.00 (1057.50–1953.75) | 0.935 | 0.935 |
