Fig. 2 | Scientific Reports

Fig. 2

From: Cycloastragenol attenuates osteoarthritis by restoring chondrocyte senescence via the NRF2/NF-κB signaling axis

Fig. 2The alternative text for this image may have been generated using AI.

CAG ameliorates extracellular matrix metabolic homeostasis. (A–E) Western blot analysis and quantification of extracellular matrix proteins (COL2A1, ACAN, ADAMTS5, MMP3) in chondrocytes under CAG (50 μm) and TBHP (50 μm) treatments (See Supplementary Materials for original blots). n = 3. (F,G) Representative Immunofluorescence images and quantitative analysis of COL2A1, ADAMTS5. bar = 50 μm. n = 3. (H,I) Representative Immunofluorescence images and quantitative analysis of ADAMTS5. bar = 50 μm. n = 3.(J,K) Representative images and quantitative analysis Alcian blue staining of chondrocytes under different treatments. *p < 0.05; **p < 0.01; ***p < 0.001.

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