Fig. 5 | Scientific Reports

Fig. 5

From: Cycloastragenol attenuates osteoarthritis by restoring chondrocyte senescence via the NRF2/NF-κB signaling axis

Fig. 5The alternative text for this image may have been generated using AI.

CAG mitigates ECM dysfunction through NRF2 activation. (A–E) Western blot analysis and quantification of extracellular matrix proteins (COL2A1, ACAN, ADAMTS5, MMP3) in chondrocytes under NRF2 inhibition treatment (See Supplementary Materials for original blots). n = 3. (F,G) Representative images and quantitative analysis alcian blue staining of chondrocytes under si-NRF2 transfection treatment. (H,I) Representative immunofluorescence images and quantitative analysis of COL2A1. n = 3. (J,K) Representative immunofluorescence images and quantitative analysis of ADAMTS5. n = 3. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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