Fig. 5
From: Prevalence and management practices of ophthalmic lesions in laboratory mice
Representative images of lens-associated alterations and histological evaluation (A) Representative image of healthy mouse eye showing smooth and shiny cornea and connective membrane. The light passes completely through the uncloudy lens and is reflected by the retina as a black area. (B)Slit lamp examination shows light reflections of the lens fibers (C) Slit lamp examination shows changes at the bottom edge of the iris that are also easily recognized by the reflection of the lens structure and would not have been immediately noticeable when viewed with a magnifying glass (D) Small area with incipient cataract (arrow head) (E) Pre-mature cataract (image from C) with opacification of the lens (F) Mature cataract (image from C) with even more pronounced lens fiber changes than in E (G) Normal architecture of lens fibers (H&E stain) (H) Swelling of lens fibers results in altered structure and staining intensity (H&E stain) (I) Markedly swollen lens fibers and irregular cellular architecture underneath the lens epithelia cell layer (H&E stain).
