Fig. 5
Native liver survival after KPE comparing patients with and without hBD1 upregulation and grouped by age at KPE. Kaplan-Meier estimator curves for native liver survival at the time of KPE in eBA discriminating (A) between eBA patients with or without upregulation of hBD1 liver expression as measured by RT-PCR (normalized to GAPDH), (B) between indicated age groups in eBA at the time of KPE, and (C) between eBA patients combining presence or absence of hBD1 upregulation in the liver and ≤ or > 45 days of age at the time of KPE. The dotted lines represent 95% confidence intervals. χ2 and p values are indicated in each figure, while significant p values are marked in red. An upregulation of hBD1 in eBA was defined as a fold-change above the upper confidence limit of the 95% confidence interval of normal control liver expression. Abbreviations: eBA, early biliary atresia; KPE, Kasai portoenterostomy; NLS, native liver survival.
