Fig. 2
From: Change in the chondroitin/dermatan structure in distal lung tissue from COPD patients
GAG analysis in COPD lung tissues. Quantification of GAGs in distal lung tissue from controls (n = 11), control smokers (n = 11) and COPD patients in GOLD stage II-III (n = 11) and GOLD stage IV (n = 11). (A) Total GAG, CS/DS, HA and HS, was quantified as the sum of relevant AMAC-derivatized disaccharides. (B) Quantification of HS disaccharides, (C) Quantification of CS/DS disaccharides, (D) Quantification of DS disaccharides following chondroitinase B digestion. Due to limited tissue supply, there were only 9 subjects in the control group and in the GOLD stage IV group for this analysis. # comparison to controls, * comparison to control smokers. Data is presented as mean ± S.D., *p < 0.05, **p < 0.01 and ***P < 0.001 using Kruskal–Wallis tests combined with Dunn’s multiple comparison test.
