Fig. 3
From: Change in the chondroitin/dermatan structure in distal lung tissue from COPD patients
Expression of biosynthetic GAG enzymes in COPD lung tissues. Gene expression profiling of COPD tissues from cohort 2 using RNAseq. (A) Volcano plot of the differential expression of COPD (GOLD stage I-II, n = 96) versus. control tissues (n = 91) highlighting the genes corresponding to the biosynthetic enzymes of the glycosaminoglycans. Cut-offs: −0.3 < log Fold Change < 0.3; adj.p-value < 0.05. (B) Gene expression of CS/DS-related biosynthetic genes in FPKM, (C) Gene expression of HS-related biosynthetic genes in FPKM, (D) Gene expression of core related genes. * adj.p-value < 0.05, ** adj.p-value < 0.01 and *** adj.p-value < 0.001 using empirical Bayes analysis (limma) and adjusted with FDR via Benjamini-Hochberg. Reported p-value in plot title is the adjusted-p-value.; Genes of other biosynthetic enzymes are in supplemental figure S3.
