Table 10 Pharmacokinetic and Toxicology of the Isomers of Terpinen-7-al
Parameter | α-Terpinen-7-al | γ-Terpinen-7-al |
|---|---|---|
Absorption & Distribution | ||
GI Absorption | High | High |
P-gp Substrate | No | No |
BBB Penetration | Yes | Yes |
Bioavailability Score | 0.55 | 0.55 |
Log S (SILICOS-IT) (Solubility) | −1.8 | −1.8 |
Metabolism | ||
CYP1A2 Inhibitor | No | No |
CYP2D6 Inhibitor | No | No |
CYP2C19 Inhibitor | No | No |
CYP2C9 Inhibitor | No | No |
CYP3A4 Inhibitor | No | No |
Toxicity | ||
Hepatotoxicity | No | No |
AMES Toxicity (Mutagenicity) | No | No |
Carcinogenicity | No | No |
hERG Inhibition (Cardiotoxicity) | No | No |
