Table 9 Bioactivities and pharmacokinetics of selected phytochemicals.
Compound | P-gp | CYP1A2 | CYP2C19 | CYP2C9 | CYP2D6 | CYP3A4 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2-Oxatricyclo [4.3.1.0(3,8)] Decane | No | – | – | – | – | – | ||||||||||
Ellagic acid | No | + | – | – | – | – | ||||||||||
Gallic acid | No | – | – | – | – | – | ||||||||||
Pulegone | No | – | – | – | – | – | ||||||||||
Compound | GPCR L | ICM | KI | NRL | PI | EI | GI | BBB | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2-Oxatricyclo [4.3.1.0(3,8)] decane | – 0.42 | – 0.70 | – 1.18 | – 0.94 | – 0.63 | 0.23 | High | Yes | ||||||
Ellagic acid | – 0.29 | – 0.27 | – 0.01 | 0.11 | – 0.18 | 0.17 | High | No | ||||||
Gallic acid | – 0.77 | – 0.26 | – 0.88 | – 0.52 | – 0.94 | – 0.17 | High | No | ||||||
Pulegone | – 1.33 | – 0.81 | – 2.13 | – 0.86 | – 1.09 | – 0.48 | High | Yes | ||||||
