Fig. 5
From: Cholesterol-rich diet exacerbates steatohepatitis in the STAM mouse model
Cholesterol-enriched high-fat diet elevates hepatic fibrosis in STZ-treated mice. (A) Representative Sirius red staining of liver sections from mice at 8, 12 or 16 weeks of age (scale bars, 50 μm). Gene expression of (B) collagen type 1 (Col1a1), (C) transforming growth factor β1 (Tgfb1), and (D) osteopontin (Spp1). Values are median (line), upper- and lower quartile (box) and extremes (whiskers) (n = 5–8/group). Data are analyzed by Kruskal-Wallis test for independent time points. *p < 0.05; **p < 0.01 ***p < 0.001.
