Table 4 Discrimination and calibration metrics of biomarker scores for predicting mortalities.

From: Prognostic performance of clinical scores and biomarkers in nonagenarians after TAVR requiring ICU admission

Variable	Outcome	AUC	CI lower	CI upper	Threshold	Sensitivity	Specificity	Cutoff
Lactate	ICU mortality	0.771	0.360	0.990	0.007	0.667	0.969	3.30
Heart rate (Lowest)	ICU mortality	0.622	0.540	0.704	0.003	1.000	0.452	60.50
MAP (Lowest)	ICU mortality	0.745	0.471	0.997	0.027	0.500	0.991	44.50
Potassium (High)	ICU mortality	0.795	0.453	0.985	0.008	0.667	0.944	5.05
Bicarbonate (Low)	ICU mortality	0.649	0.270	0.866	0.008	0.667	0.809	21.05
Creatinine (High)	ICU mortality	0.593	0.361	0.741	0.005	0.667	0.691	108.50
Creatinine (Low)	ICU mortality	0.517	0.268	0.678	0.007	0.667	0.647	75.50
Glucose (High)	ICU mortality	0.858	0.800	0.907	0.005	1.000	0.794	8.45
PaO₂	ICU mortality	0.750	0.495	0.959	0.010	0.667	0.801	74.50
Urea	ICU mortality	0.599	0.392	0.728	0.005	1.000	0.379	7.15
Albumin	ICU mortality	0.515	0.034	0.991	0.012	0.333	0.990	45.50
Bilirubin	ICU mortality	0.644	0.427	0.938	0.005	1.000	0.359	9.50
Lactate	Hospital mortality	0.860	0.708	0.980	0.020	0.778	0.959	2.45
Heart rate (Lowest)	Hospital mortality	0.475	0.290	0.660	0.014	0.500	0.599	62.50
MAP (Lowest)	Hospital mortality	0.747	0.598	0.898	0.008	1.000	0.470	66.50
Potassium (High)	Hospital mortality	0.700	0.512	0.863	0.015	0.667	0.648	4.45
Bicarbonate (Low)	Hospital mortality	0.686	0.497	0.839	0.025	0.556	0.812	21.05
Creatinine (High)	Hospital mortality	0.658	0.490	0.800	0.016	0.667	0.694	108.50
Creatinine (Low)	Hospital mortality	0.585	0.410	0.751	0.017	1.000	0.255	67.50
Glucose (High)	Hospital mortality	0.843	0.723	0.935	0.016	0.889	0.746	7.95
PaO₂	Hospital mortality	0.776	0.641	0.884	0.025	0.778	0.722	78.50
Urea	Hospital mortality	0.728	0.598	0.851	0.015	0.889	0.506	7.95
Albumin	Hospital mortality	0.541	0.317	0.754	0.018	0.333	0.956	40.50
Bilirubin	Hospital mortality	0.658	0.477	0.832	0.020	0.444	0.817	17.50
Lactate	1-month mortality	0.780	0.651	0.896	0.024	0.692	0.747	1.25
Heart rate (Lowest)	1-month mortality	0.526	0.364	0.665	0.021	0.583	0.602	62.50
MAP (Lowest)	1-month mortality	0.655	0.507	0.811	0.017	0.833	0.471	66.50
Potassium (High)	1-month mortality	0.664	0.479	0.828	0.023	0.615	0.739	4.55
Bicarbonate (Low)	1-month mortality	0.621	0.469	0.760	0.033	0.462	0.811	21.15
Creatinine (High)	1-month mortality	0.588	0.471	0.699	0.023	0.615	0.657	104.50
Creatinine (Low)	1-month mortality	0.518	0.386	0.645	0.028	0.923	0.255	67.50
Glucose (High)	1-month mortality	0.732	0.578	0.865	0.023	0.692	0.745	7.95
PaO₂	1-month mortality	0.709	0.580	0.822	0.014	1.000	0.346	111.50
Urea	1-month mortality	0.634	0.463	0.791	0.023	0.615	0.696	9.55
Albumin	1-month mortality	0.577	0.375	0.766	0.030	0.333	0.958	40.50
Bilirubin	1-month mortality	0.607	0.421	0.782	0.034	0.333	0.919	22.50
Lactate	6-month mortality	0.633	0.519	0.745	0.059	0.484	0.750	1.25
Heart rate (Lowest)	6-month mortality	0.530	0.438	0.620	0.056	0.788	0.321	58.50
MAP (Lowest)	6-month mortality	0.538	0.430	0.644	0.068	0.212	0.909	54.50
Potassium (High)	6-month mortality	0.615	0.511	0.719	0.056	0.706	0.517	4.35
Bicarbonate (Low)	6-month mortality	0.559	0.440	0.680	0.063	0.400	0.817	21.15
Creatinine (High)	6-month mortality	0.590	0.487	0.686	0.059	0.588	0.665	104.50
Creatinine (Low)	6-month mortality	0.536	0.429	0.643	0.066	0.500	0.615	94.50
Glucose (High)	6-month mortality	0.637	0.521	0.742	0.062	0.500	0.808	8.45
PaO₂	6-month mortality	0.579	0.479	0.679	0.058	0.774	0.420	104.50
Urea	6-month mortality	0.664	0.563	0.762	0.059	0.588	0.694	9.35
Albumin	6-month mortality	0.617	0.507	0.730	0.065	0.379	0.815	28.50
Bilirubin	6-month mortality	0.572	0.449	0.684	0.061	0.379	0.794	16.50
Lactate	1-year mortality	0.628	0.544	0.712	0.092	0.531	0.698	1.15
Heart rate (Lowest)	1-year mortality	0.554	0.478	0.625	0.089	0.836	0.293	57.50
MAP (Lowest)	1-year mortality	0.560	0.474	0.644	0.127	0.164	0.960	51.50
Potassium (High)	1-year mortality	0.597	0.509	0.682	0.102	0.464	0.752	4.55
Bicarbonate (Low)	1-year mortality	0.545	0.444	0.640	0.097	0.362	0.822	21.15
Creatinine (High)	1-year mortality	0.587	0.504	0.667	0.096	0.527	0.669	104.50
Creatinine (Low)	1-year mortality	0.537	0.446	0.622	0.102	0.620	0.502	85.50
Glucose (High)	1-year mortality	0.649	0.563	0.729	0.100	0.463	0.797	8.15
PaO₂	1-year mortality	0.571	0.491	0.645	0.096	0.765	0.427	104.50
Urea	1-year mortality	0.635	0.552	0.716	0.092	0.696	0.520	7.95
Albumin	1-year mortality	0.576	0.484	0.660	0.100	0.408	0.724	29.50
Bilirubin	1-year mortality	0.610	0.525	0.695	0.094	0.510	0.683	13.50
Lactate	Long-term mortality	0.603	0.551	0.653	0.319	0.626	0.551	0.95
Heart rate (Lowest)	Long-term mortality	0.565	0.518	0.612	0.295	0.895	0.235	54.50
MAP (Lowest)	Long-term mortality	0.573	0.518	0.622	0.351	0.472	0.634	63.50
Potassium (High)	Long-term mortality	0.579	0.529	0.629	0.355	0.359	0.776	4.55
Bicarbonate (Low)	Long-term Mortality	0.575	0.521	0.628	0.359	0.308	0.845	21.60
Creatinine (High)	Long-term mortality	0.587	0.539	0.636	0.320	0.656	0.479	87.50
Creatinine (Low)	Long-term mortality	0.561	0.507	0.616	0.314	0.580	0.523	85.50
Glucose (High)	Long-term mortality	0.591	0.545	0.641	0.309	0.649	0.503	6.65
PaO₂	Long-term mortality	0.568	0.518	0.617	0.382	0.470	0.637	87.50
Urea	Long-term mortality	0.585	0.532	0.636	0.299	0.737	0.405	7.05
Albumin	Long-term mortality	0.599	0.546	0.648	0.330	0.676	0.483	32.50
Bilirubin	Long-term mortality	0.560	0.507	0.613	0.342	0.409	0.703	13.50

AUROC values and 95% CIs quantify discriminatory ability of individual biomarkers. Cutoffs were derived from Youden’s index. Sensitivity and specificity reflect classification performance at these thresholds. All biomarkers were measured within the initial 24 h of ICU admission. Variables include both physiologic parameters and laboratory data routinely collected in critical care.

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Table 4 Discrimination and calibration metrics of biomarker scores for predicting mortalities.

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