Table 1 Characteristics of all patients included (n = 798), and as per type of operation.

From: Optimized CAP cut-offs for metabolic dysfunction associated steatotic liver disease in patients living with obesity: a large biopsy-based prospective study

Variable

All patients

n = 798 (100%)

Laparoscopic cholecystectomy (LC) n = 629 (78.8%)

Laparoscopic sleeve gastrectomy (LSG) n = 169 (21.2%)

P value

Age (years)

40 (32–48)

41 (33–50)

36 (29-43.5)

< 0.001

Sex Male

Female

154 (19.3)

644 (80.7)

117 (18.6)

512 (81.4)

37 (21.9)

132 (78.1)

0.336

BMI (kg/m2)

34.9 (29.8–41.2)

33.4 (29.4–38.7)

43.9 (34.7–50.1)

< 0.001

ALT (IU/L)

18 (13.4–26.5)

18.1 (14–27)

16.1 (12.1–24.0)

0.015

AST (IU/L)

18 (15–22)

18.0 (15.0–22.0)

16.5 (13.1–21.0)

0.012

ALP (IU/L)

77 (63–97)

79.4 (63.1–99.0)

73.0 (57.2–93.0)

0.027

Total Bilirubin (mg/dL)

0.57 (0.50–0.80)

0.59 (0.50–0.80)

0.54 (0.50–0.82)

0.625

Albumin (g/dL)

4.3 (4.1–4.5)

4.3 (4.1–4.5)

4.3 (4.1–4.5)

0.857

Platelets (x106/mL)

253 (208.8–304)

254 (208.5-300.9)

253 (209.5-309.5)

0.633

Hb (g/dL)

12.4 (11.5–13.3)

12.4 (11.5–13.3)

12.4 (11.5–13.4)

0.924

RBCs (x103/mL)

4.7 (4.4-5.0)

4.7 (4.4–5.1)

4.7 (4.4-5.0)

0.454

WBCs (x103/mL)

7.2 (5.5–9.3)

7.1 (5.6–9.1)

7.2 (5.3–9.7)

0.849

LSM (kPa, range 1.5–75)

4.9 (4.0-6.4)

4.8 (3.9–6.1)

5.8 (4.4–8.7)

< 0.001

CAP (dB/m, range 100–400)

263 (214–311)

258 (213–301)

298 (225–342)

< 0.001

LIVER BIOPSY Fibrosis stage (METAVIR)

F0

434 (54.4)

323 (51.4)

111 (65.7)

0.011

F1

315 (39.5)

263 (41.8)

52 (30.8)

 

F2

32 (4.0)

28 (4.5)

4 (2.4)

 

F3

9 (1.1)

9 (1.4)

0 (0.0)

 

F4

8 (1.0)

6 (1.0)

2 (1.2)

 

LIVER BIOPSY Steatosis stage

S0

580 (72.7)

521 (82.8)

59 (34.9)

< 0.001

S1

157 (19.7)

86 (13.7)

71 (42.0)

 

S2

56 (7.0)

20 (3.2)

36 (21.3)

 

S3

5 (0.6)

2 (0.3)

3 (1.8)

 
  1. Data expressed as median (interquartile range, IQR) or number (percentage). ALP; alkaline phosphatase, ALT: alanine aminotransferase. AST: aspartate aminotransferase. BMI; body mass index. CAP: controlled attenuation parameter. Hb; hemoglobin. LB; Liver Biopsy. LSM; liver stiffness measure. n; number. NAS: nonalcoholic steatohepatitis scoring. RBCs; red blood cells. WBCs: white blood cells.