Fig. 5 | Scientific Reports

Fig. 5

From: The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration

Fig. 5The alternative text for this image may have been generated using AI.

AlphaFold3-predicted model of the C16orf87–HDAC1–MIER1 complex. (A) Cartoon representation of the top-ranked predicted complex showing C16orf87 (pastel green), HDAC1 (peach), and MIER1 (lavender grey). The arrow indicates Ser91 in C16orf87. N, N-terminus; C, C-terminus. (B) The same model colored by per-residue confidence (pLDDT). Interface predicted TM-score (ipTM) and predicted TM-score (pTM) values for the top-ranked model are shown. (C) Surface representation of HDAC1 (peach) and MIER1 (lavender grey) with C16orf87 (pastel green) displayed as a cartoon model. (D) View of the model in (C) rotated 90° around the vertical axis. Residues lining the catalytic pocket of HDAC1 are highlighted in yellow. Figures were rendered using ChimeraX (version 1.8, https://www.rbvi.ucsf.edu/chimerax62).

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