Fig. 7
C16orf87 deficiency affects the embryonic development of zebrafish. (A) Lateral view of a C7H16orf87 (human C16orf87 ortholog) crispant larvae versus its sibling control, highlighting some developmental traits examined: eye (blue), body surface area (blue lines/contour), head-to-back angle (green lines), and curvature of the back (red curve). (B) Margins and scatter plots of the most representative developmental traits measured (eye area, head-to-back to angle, length, back curvature) in crispants (orange) and controls (grey) are adjusted for time of imaging. Each orange/grey dot is a larva. (C) Forest plot of effect size (dot) and confidence intervals (lines) for the effect of mutations in C7H16orf87 vs. sibling controls on developmental traits expressed in SD units. Linear regression analyses were adjusted for time of imaging. Zero (red line) corresponds to no difference between crispants and controls.
