Fig. 1

Relative expression levels of the miRNAs with different representation found in plasma of FRDA patients compared to healthy control participants. Box plot of plasma levels of (a) hsa-miR-128-3p; (b) hsa-miR-625-3p, (c) hsa-miR-130b-5p, (d) hsa-miR-151a-5p, (e) hsa-miR-330-3p, (f) hsa-miR-323a-3p, and (g) hsa-miR-142-3p in healthy participants (Controls) (n = 34) and FRDA patients (n = 34). Expression levels of the miRNAs were normalized to miR-16-5p. The lines inside the boxes denote the medians. The boxes mark the interval between the 25th and 75th percentiles. The whiskers denote the interval between the 10th and 90th percentiles. Filled circles indicate data points outside the 10th and 90th percentiles. Statistically significant differences were determined using Mann-Whitney tests. All P-values were two-tailed and less than 0.05 was considered statistically significant. P-values were unadjusted for multiple comparisons.