Fig. 3

Relative expression levels of the miRNAs with different representation found in plasma of FRDA patients with and without cardiomyopathy. Box plot of plasma levels of (a) hsa-miR-323a-3p; (b) hsa-miR-128-3p; (c) hsa-miR-142-3p; (d) hsa-miR-625-3p; (e) hsa-miR-330-3p, (f) hsa-miR-151a-5p, and (g) hsa-miR-130b-5p in FRDA patients without cardiomyopathy (No Cardio; n = 17) and FRDA patients with cardiomyopathy (Cardio; n = 15). Expression levels of the miRNAs were normalized to miR-16-5p. The lines inside the boxes denote the medians. The boxes mark the interval between the 25th and 75th percentiles. The whiskers denote the interval between the 10th and 90th percentiles. Filled circles indicate data points outside the 10th and 90th percentiles. Statistically significant differences were determined using Mann-Whitney tests. All P-values were two-tailed and less than 0.05 was considered statistically significant.