Table 1 Area under ROC curves for diagnosis of hypertrophic cardiomyopathy in FRDA patients.

From: Validation of circulating miR-323a-3p and miR-625-3p to classify hypertrophic cardiomyopathy in Friedreich’s ataxia

miRNA

AUC

Standard error

95% CI

p-value

Fold change optimal cut-off value

Sensitivity (%)

Specificity (%)

miR-323a-3p

0.726

0.09

0.546, 0.912

0.039*

> 1.41

76.92

62.50

miR-625-3p

0.731

0.09

0.535, 0.927

0.035*

< 0.91

69.54

62.50

LVEF

0.513

0.12

0.286, 0.740

0.905

< 64.5

57.14

47.06

LVEDd

0.513

0.12

0.286, 0.740

0.908

> 44.50

53.85

46.67

LVESd

0.523

0.12

0.291, 0.754

0.836

< 28.5

61.54

40.00

IVS

0,809

0.08

0.645, 0,972

0.004*

> 11.5

60.00

100.00

LVPWT

0.771

0.09

0.594, 0.949

0.010*

> 11.5

28.57

93.33

RWT

0.703

0.10

0.500, 0.905

0.070

> 0.4250

61.54

60.00

  1. Interventricular septal thickness (IVS), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic diameter (LVEDd), left ventricular end-systolic diameter (LVESd), ejection fraction (LVEF), Relative Wall Thickness (RWT), area under the curve (AUC) and confidence interval (CI). * Indicates significative p-value.
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