Table 3 Sites of head and neck SPM compared to index head and neck carcinoma site

From: Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy

Index cancer site

Primary site of SPM

Number of cases (n = 36)

Tonsil (n = 18)

Oral tongue

7

Larynx

3

Thyroid

2

Base of tongue

2

Parotid

1

Retromolar trigone

1

Tonsil (contralateral)

1

Base of tongue (n = 14)

Larynx

7

Oral tongue

3

Gingiva

2

Base of tongue

1a

Tonsil

1

Soft palate

Retromolar trigone

1

Nasopharynx

Oral tongue

1

Maxillary sinus

Hard palate

1b

Retromolar trigone

Base of tongue

1

  1. aSecond base of tongue cancer was located away from index tumor location and diagnosed at >10 years from the index cancer
  2. bThe second tumor was of a different histology than the index cancer
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