Fig. 6: Synergistic activation of mutant TERT promoter by Sp1 and GABPA.
From: Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers
a In vitro luciferase assay was performed to determine synergistic effect of GABPA and Sp1 on the activity of mutant TERT promoter in the indicated cells. b TARP assay was performed to determine the synergistic effect of GABPA and Sp1 on TERT reactivation. c ChIP-qPCR assay was performed to determine the synergistic effect of GABPA and Sp1 on histone modifications (including H3K9ac and H3K27me3) of TERT promoter in the indicated cells. Data were shown as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001.
