Fig. 8: A schematic model showing the activation of the mutant TERT promoter by the synergistic interaction between Sp1 and GABPA.
From: Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers
In BRAFV600E-driven cancer cells, GABP tetramer mediates the recruitment of activated ERK to mutant TERT promoter. In turn, activated ERK facilitates the interaction between Sp1 and GABPA by phosphorylating Sp1 and subsequently promoting HDAC1 dissociation from Sp1/HDAC1 complex, further enhancing the binding of GABPA to mutant TERT promoter. Synergistic interaction between Sp1 and GABPA will maintain an active chromatin state in mutant TERT promoter.
