Fig. 6: PD-L1, LAG-3, and TLR2 correlate to most abundant vaginal bacterial species. | npj Precision Oncology

Fig. 6: PD-L1, LAG-3, and TLR2 correlate to most abundant vaginal bacterial species.

From: Vaginal microbiota, genital inflammation, and neoplasia impact immune checkpoint protein profiles in the cervicovaginal microenvironment

Fig. 6

PD-L1 and LAG-3 negatively correlated to Lactobacillus species and positively correlated to dysbiotic bacteria, whereas TLR2 negatively correlated to dysbiotic bacteria and positively correlated to lactobacilli. Spearman correlation coefficients (ρ) were calculated using levels of immune checkpoint proteins for all samples (n = 78) and relative abundances/levels of vaginal bacterial taxa. Relative abundances of most prevalent vaginal genera (i.e., Lactobacillus, Gardnerella, Sneathia, Prevotella, Atopobium, Megasphaera, and Streptococcus) were determined by 16S rRNA gene sequencing. Relative levels of vaginal Lactobacillus species (L. crispatus, L. gasseri, L. jensenii, and L. iners) were determined by quantitative real-time PCR assays. P values are indicated with asterisks (***P < 0.001; **P < 0.01; *P < 0.05).

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