Fig. 3: Survival of dogs treated with c4G12.

a Comparison of survival between c4G12 treatment group (n = 29) and historical control group (n = 15). Survival (days) was defined as time from confirmation of pulmonary metastasis to death. For subgroup analysis, the treatment group was dichotomized according to (b) the use of previous/concomitant radiation, (c) plasma C reactive protein (CRP) levels (cutoff 2.55 mg/dL), or (d) the lymphocyte-to-monocyte ratio (LMR, cutoff 1.41), and overall survival was compared between the subgroups. Dogs that received radiation therapy concomitantly or ≤8 weeks before the initiation of antibody treatment were classified into radiation (+) subgroup. Marks on the line indicate censored data. Statistical analysis was performed using the log-rank test.